Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer Development and Application Funding sources:
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Recent publications: Zhang, K., Nie, Q., Lau, C. K., Kwok, C. K. Rational Design of L-RNA Aptamer-Peptide Conjugate for Efficient Cell Uptake and G-quadruplex-Mediated Gene Control. Angewandte Chemie. e202310798 (2024) Ji, D., Yuan, J., Chen, S., Tan, J., Kwok, C. K. Selective targeting of parallel G-quadruplex structure using L-RNA aptamer. Nucleic Acids Research. 51, 11439–11452 (2023) Mou, X., Kwok, C. K. Peptides Selected by G4-mRNA Display-Seq Enable RNA G-Quadruplex Recognition and Gene Regulation. JACS. 145, 18693−18697 (2023) Lyu, K., Kwok, C. K. RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays. Methods in Enzymology. 691, 63-80 (2023) Lyu, K., Kwok, C. K. A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression. ChemComm. 59, 8230 - 8233 (2023). Ji, D., Feng, H., Liew, S. W., Kwok, C. K. Modified nucleic acid aptamers: development, characterization, and biological applications. Trends in Biotechnology. 41(11), P1360-P1384 (2023). Shiu, S. C., Kinghorn, A. B., Guo, W., Slaughter, L. S., Ji, D., Mo, X., Wang, L., Tran, N. C., Kwok, C. K., Shum, A. H. C., Tse, E. C. M., Tanner, J. A. Aptamers as Functional Modules for DNA Nanostructures. Methods Mol Biol. 2639, 301-337 (2023). |
Recent lab news: Mar 2024: Congrats to Kaixin on awarding the Outstanding Research Thesis Award 2023! Feb 2024: Congrats to Jesslyn on awarding HKSAR Government Scholarship 2023/2024! Feb 2024: Congrats to Caroline and Kun on awarding the RNA Society Research Presentation Fellowship! Jan 2024: Paper published in Angewandte Chemie. Congrats to Kun! Oct 2023: Paper published in Nucleic Acids Research. Congrats to Danyang! Aug 2023: Congrats to Sally on winning Outstanding Academic Performance Award (OAPA)! Aug 2023: Paper published in JACS. Congrats to Xi! Jun 2023: Paper published in Methods in Enzymology. Congrats to Kaixin! Jun 2023: CSCI Excellent Paper Award for Research Students. Congrats to Danyang, Sally and Caroline! Jun 2023: Paper published in ChemComm. Congrats to Kaixin! Jun 2023: Paper published in Trends in Biotechnology. Congrats to Danyang, Sally and Caroline! |